Dr. Şermin Genç was graduated from Medical Faculty of Ege University in 1992. She finished Neurology residency in 1998 and earned her PhD degrees from Department of Medical Biology and Genetic in 2003 at Dokuz Eylul University. She has been working as a Professor at Department of Neuroscience, Dokuz Eylul University. She is also a research group leader in İzmir Biomedicine and Genome Center since 2015. Her group investigates the molecular mechanisms that underlie cell death in neurodegeneration and neuroinflammation and assess novel strategies for neuroprotection. Recent years, her group focuses on exosomal content analysis to develop potential diagnostic/prognostic biomarkers in several neurological and psychiatric disorders. She has received some prestigious awards including Loreal Women in Science, TUBA-GEBIP, Incentive award from TUBİTAK and Science award from Eczacıbaşı.
Title: The impact of exosomes in brain disorders: from pathogenesis to clinical application
Exosomes are small membrane vesicles released under normal or pathological conditions from various cells. They are distinguished from membrane vesicles by their size (40-100 nm). Features of exosomes like cytoplasm surrounded with lipid bilayer. Their release occurs by fusion of multi-vesicular structures and differentiation from the plasma membrane. Today, exosomes have been shown to be present in all body fluids, including brain-spinal fluid. They carry several cargo molecules including mRNA, protein and miRNA. In fact, RNA-containing exosomes were described in the late 1900's. These RNA molecules are transferred to other cells and the transferred mRNA molecules in the target cell are converted to protein while the miRNAs modulate gene expression.
In recent years, several studies showed that exosomes have important role in the development and progression of brain disorders. Additionally, exosomal cargo molecules such as miRNAs can be isolated from blood and used as potential novel diagnostic and prognostic biomarkers for several brain diseases. Also, exosomes are good drug-carrier due to their low immunogenicity and toxicity, high stability in circulation and tissue, and accumulation in the target tissue.
1. Zhang et al(2019). Nat Rev Neurol 10.1038/s41582-018-0126-4.
2. Shi et al(2019). Nat Rev Neurol Prog Neurobiol 10.1016/j.pneurobio.
3. Osorio-Querejeta et al(2018).Front Mol Neurosci 10.3389/fnmol.
4. Osier et al(2018). Mol Neurobiol. 10.1007/s12035-018-1054-4.
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